Post-Exposure Prophylaxis (PEP)

What is PEP?

PEP is a way to stop HIV infection after a possible exposure –  for example, if a condom breaks, if you forget to use one, if you have been sexually assaulted, or if you had unprotected sex and are unsure of the status of your partner.

You must start PEP within 72 hours after the exposure for it to work. You should come in for PEP as soon as possible after an exposure.

PEP medication must be taken for approximately a month (28 days) consecutively after the exposure.

Do I need PEP?

Here are some cases when you may want PEP:

  • A condom breaks during sex
  • You forget to use a condom during sex
  • A partner finds out/discloses they are HIV positive after you have had unprotected sex
  • You share a needle or syringe with someone to inject drugs or hormones
  • You get “stuck” by a needle at your job that was used on someone else
  • You experience sexual assault

If you want to talk to someone about whether you need PEP, call us at (212) 271-7200

How can I access PEP?

You do not have to be a patient already at Callen-Lorde to get PEP. Anyone can walk in for PEP consultation Anyone can walk in for PEP during between the hours of 8:30 am – 6:00 pm Monday – Thursday, 8:30 am – 2:30 pm Friday, 8:30 am – 12:30 pm Saturday. To get PEP, you must come to the clinic within 72 hours of potential exposure to HIV. It can take up to 2-3 hours to get PEP at Callen-Lorde.

Do I need insurance? How do I pay for it?

PEP is covered by most insurance programs, but you do not need insurance to get PEP at Callen-Lorde. If you are uninsured, one of our Prevention Outreach Providers will help you to enroll in a program that makes PEP available to uninsured patients for free.

I am a patient but Callen-Lorde is closed. What do I do?

It’s important to start PEP as soon as possible after exposure. You can get PEP at your local emergency room if Callen-Lorde is closed. You can also go to this website: and put in your zip code to find all the clinics/hospitals near you that provide PEP.

Are the side effects really bad?

PEP often doesn’t cause any side effects in people who take it. The most common side effects are indigestion, nausea, gas, or bloating, but they usually go away within a couple of days. If are worried about side effects, please call us at (212) 271-7200.